Base Editors
Base editors enable precise single-nucleotide changes without double-strand breaks. Cytosine base editors (CBEs) convert C-to-T, adenine base editors (ABEs) convert A-to-G, covering all four transition mutations that account for roughly half of known pathogenic variants. Enhanced variants like ABE8e and BE4max improve efficiency while maintaining the safety profile that distinguishes base editing from nuclease-based approaches.
| Name | Type | Conversion | Editing Window |
|---|---|---|---|
| ABE C-term | Adenine Base Editor | A-to-G | Positions 4-7 |
| ABE N-term | Adenine Base Editor | A-to-G | Positions 4-7 |
| ABE7.10 | Adenine Base Editor | A-to-G | Positions 4-7 |
| ABE8e | Adenine Base Editor | A-to-G | Positions 4-9 (wider) |
| AncBE4max | Cytosine Base Editor | C-to-T | Positions 5-6 (narrower) |
| BE3 | Cytosine Base Editor | C-to-T | Positions 4-8 |
| BE3.9max C-term | Cytosine Base Editor | C-to-T | Positions 4-8 |
| BE3.9max N-term | Cytosine Base Editor | C-to-T | Positions 4-8 |
| BE4max | Cytosine Base Editor | C-to-T | Positions 4-8 |
| CBE C-term | Cytosine Base Editor | C-to-T | Positions 4-8 |
| CBE N-term | Cytosine Base Editor | C-to-T | Positions 4-8 |
| CGBE | C-to-G Base Editor | C-to-G | Positions 4-8 |
| CjABE8e | Adenine Base Editor | A-to-G | 3-11 |
| Nme2ABE8e | Adenine Base Editor | A-to-G | 4-10 |
| SaABE8e | Adenine Base Editor | A-to-G | 4-9 |
| SaABE8e-V106W | Adenine Base Editor | A-to-G | 4-9 |
| SaBE3.9max C-term | Cytosine Base Editor | C-to-T | Positions 4-8 |
| SaBE3.9max-KKH C-term | Cytosine Base Editor | C-to-T | Positions 4-8 |
| SaBE3.9max N-term | Cytosine Base Editor | C-to-T | Positions 4-8 |
| SaCBE C-term | Cytosine Base Editor | C-to-T | Positions 4-8 |
| SaCBE-KKH C-term | Cytosine Base Editor | C-to-T | Positions 4-8 |
| SaCBE N-term | Cytosine Base Editor | C-to-T | Positions 4-8 |
| SaKHH-ABE8e | Adenine Base Editor | A-to-G | 4-9 |
| SauriABE8e | Adenine Base Editor | A-to-G | 4-9 |
| Target-AID | Adenine Base Editor | A-to-G (via C-to-T intermediate) | Positions 2-4 (narrower) |