U6-(gRNA)-(pro)-SauriABE8e-bGHpA
Express sgRNA under U6 and SauriABE8e under selected promoter for alternative PAM specificity and genome coverage
Characteristics
Compact Staphylococcus auricularis Cas9 architecture (~4.4 kb) enables single-AAV delivery with alternative PAM specificity. Uses 21-nucleotide protospacer. Editing window spans positions 4-9. Compatible with SaCas9 sgRNA scaffolds. Part of three-editor suite collectively targeting ~82% of genomic adenines.
Parts
Custom Inserts
SauriCas9 gRNA Target
(21-21 bp)
Literature Sources
- Davis et al. (2022). Efficient in vivo base editing via single adeno-associated viruses with size-optimized genomes encoding compact adenine base editors. Nat Biomed Eng.
Available Products
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Custom Adenine Base Editor (Plasmid)
Regular price From $595Regular priceUnit price per -
Custom Adenine Base Editor (AAV)
Regular price From $1,995Regular priceUnit price per
Additional Information
Applications: Genomic sites inaccessible to SaCas9, Nme2Cas9, and CjCas9 PAM requirements. Multi-editor therapeutic strategies requiring different PAM specificities for targeting multiple loci simultaneously. Complementary to other compact editors for expanding overall targeting scope and genome coverage.