U6-(gRNA)-(pro)-CjABE8e-bGHpA
Expresses sgRNA under U6 and CjABE8e under selected promoter for ultra-compact single-AAV delivery
Characteristics
Smallest base editor architecture (~3.8 kb total) using ultra-compact Campylobacter jejuni Cas9, leaving maximum cargo space in AAV. Uses 22-nucleotide protospacer. Editing window spans positions 3-11, providing broad positional flexibility. Part of three-editor suite collectively targeting ~82% of genomic adenines.
Parts
Custom Inserts
CjCas9 gRNA Target
(22-22 bp)
Literature Sources
- Davis et al. (2022). Efficient in vivo base editing via single adeno-associated viruses with size-optimized genomes encoding compact adenine base editors. Nat Biomed Eng.
Available Products
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Custom Adenine Base Editor (Plasmid)
Regular price From $595Regular priceUnit price per -
Custom Adenine Base Editor (AAV)
Regular price From $1,995Regular priceUnit price per
Additional Information
Applications: Applications requiring minimal editor size for incorporating additional cargo elements such as reporters, complex tissue-specific promoters, or safety switches. Complex vector designs needing multiple expression cassettes within single AAV. Complementary to SaCas9 and Nme2Cas9 editors for comprehensive genome coverage.