Collection: Epigenome Editing

Modulate gene expression without altering DNA sequence. CRISPRa for activation, CRISPRi for repression, and targeted DNA methylation/demethylation editors. Control endogenous gene expression for functional genomics, disease modeling, and therapeutic applications. Available as dCas9 fusions with transcriptional effectors, methyltransferases, or demethylases in AAV, lentiviral, and plasmid formats.

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Plasmid Vectors
Molecular biology workhorses for transgene delivery, in vitro studies, protein expression, and...

Plasmid Vectors
AAV Vectors
Adeno-associated viral vectors for in vivo and ex vivo gene delivery. From...

AAV Vectors
Transposon Vectors
DNA transposon systems for stable genomic integration without viral vectors. PiggyBac and...

Transposon Vectors
CRISPR Tools
Comprehensive CRISPR components for custom genome editing workflows. Guide RNAs, nuclease variants,...

CRISPR Tools
Base Editing
Precision single-nucleotide conversion without double-strand breaks. Adenine base editors (A→G), cytosine base...

Base Editing
Epigenome Editing
Modulate gene expression without altering DNA sequence. CRISPRa for activation, CRISPRi for...

Epigenome Editing
Prime Editing
Search-and-replace genome editing without double-strand breaks or donor templates. Prime editors enable...

Prime Editing