Single-vector CRISPR system for in vivo gene editing. SaCas9 delivers complete editing machinery in one AAV, eliminating dual-vector requirements. Established performance across CNS, liver, muscle, and other AAV-accessible tissues. Wild-type Staphylococcus aureus Cas9 (1053aa) with KKH-enhanced PAM recognition (NNGRRT). Industry-standard nuclease with validated efficiency across diverse cell types and applications1,2.
