Custom OpenCRISPR-1 Editor (Dual-AAV)

First AI-designed dual-vector CRISPR system. OpenCRISPR-1 (1380aa) matches SpCas9 on-target activity while reducing off-target editing by 95%. Compatible with canonical SpCas9 sgRNAs and existing dual-AAV workflows. Lacks immunodominant SpCas9 T cell epitopes, potentially reducing immunogenicity risk. NGG PAM with strict specificity - minimal activity at non-NGG sites enhances precision. Ideal for applications prioritizing specificity over promiscuous PAM recognition^1,2.