AAV3 Serotype
Human serotype with unique hepatocyte growth factor receptor (HGFR) usage, conferring selective human hepatocyte and cancer cell tropism. Species-specific characteristics.
Characteristics
Uses human hepatocyte growth factor receptor (HGFR/c-Met) as co-receptor. Selective for human hepatocytes - poor transduction in mouse models. Enhanced transduction of hepatocellular carcinoma cells. Two main variants: AAV3a and AAV3b with distinct capsid structures. HSPG binding for initial attachment. Species-specific tropism limits preclinical development.
Applications
Human hepatocellular carcinoma targeting (cancer gene therapy research). Human liver-directed applications requiring species-specific tropism. Liver cancer suicide gene therapy studies. Limited clinical development due to mouse model limitations.
Literature References
- Lerch et al. (2010). The structure of adeno-associated virus serotype 3B (AAV-3B): insights into receptor binding and immune evasion. Virology - Lerch 2010 AAV3B
- Ling et al. (2010). Human hepatocyte growth factor receptor is a cellular coreceptor for adeno-associated virus serotype 3. Hum Gene Ther - Ling 2010 AAV3 HGFR
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