The structure of adeno-associated virus serotype 3B (AAV-3B): insights into receptor binding and immune evasion

Lerch et al. (2010). Virology DOI: 10.1016/j.virol.2010.03.027 Citations: 142

Key findings

First crystal structure of AAV3B capsid. Demonstrated AAV3's unique use of human hepatocyte growth factor receptor (hHGFR) as a co-receptor, explaining selective tropism for human hepatocytes and liver cancer cells.