AAV-ShH10Y445F Serotype
ShH10 variant with Y445F tyrosine mutation for enhanced intracellular trafficking and 2-5 fold improved transduction in liver and muscle.
Characteristics
Y445F tyrosine mutation reducing ubiquitination. Enhanced intracellular trafficking. 2-5 fold transduction improvement versus wild-type ShH10. Maintained broad tropism profile. Reduced vector dose requirements.
Applications
Hemophilia B clinical development. Enhanced liver-directed gene therapy. Applications requiring improved transduction efficiency.
Literature References
- Hauck et al. (2020). Generation and characterization of chimeric recombinant AAV vectors. Mol Ther Methods Clin Dev - Hauck 2020 ShH10-Y445F
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