Constitutive promoter from the human ubiquitin C gene; provides stable, moderate-level expression across most mammalian cell types with reduced susceptibility to epigenetic silencing compared to viral promoters.
Length: 1178 bp
Characteristics
Constitutive, ubiquitous expression in human and mouse cells; more resistant to CpG methylation-induced silencing than CMV. Widely used in lentiviral and episomal vectors for stable long-term transgene expression.
Schorpp et al. (1996).
The Human Ubiquitin C Promoter Directs High Ubiquitous Expression of Transgenes in Mice.
Nucleic Acids Res - Schorpp 1996 UbC Promoter
Qin et al. (2010).
Systematic Comparison of Constitutive Promoters and the Doxycycline-Inducible Promoter.
PLoS ONE - Qin 2010 Promoter Comparison
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