Human synapsin 1 (hSyn/SYN1) promoter

Compact pan-neuronal promoter with high specificity across excitatory and inhibitory neurons in vitro and in vivo. Minimal activity in astrocytes, oligodendrocytes, and non-neural tissue. Standard promoter for AAV-mediated neuronal transgene expression in rodent and NHP brain.

Length: 470 bp

Strength: Moderate (in neurons)

Characteristics

Pan-neuronal ~470 bp promoter from human SYN1 gene. Drives robust expression in excitatory and inhibitory neurons with no glial activity. Extensively used in AAV CNS gene delivery.

Applications

Essential for CNS applications requiring neuronal specificity. Use for brain and spinal cord targeting when non-neuronal expression must be avoided.

Literature References

  1. Kügler et al. (2003). Human synapsin 1 gene promoter confers highly neuron-specific long-term transgene expression from an adenoviral vector in the adult rat brain. Gene Ther - Kügler 2003 hSyn