Human synapsin 1 (hSyn/SYN1) promoter

Compact pan-neuronal promoter with high specificity across excitatory and inhibitory neurons in vitro and in vivo. Minimal activity in astrocytes, oligodendrocytes, and non-neural tissue. Standard promoter for AAV-mediated neuronal transgene expression in rodent and NHP brain.

Length: 470 bp

Strength: Moderate (in neurons)

Characteristics

Pan-neuronal ~470 bp promoter from human SYN1 gene. Drives robust expression in excitatory and inhibitory neurons with no glial activity. Extensively used in AAV CNS gene delivery.

Applications: Essential for CNS applications requiring neuronal specificity. Use for brain and spinal cord targeting when non-neuronal expression must be avoided.

References

  1. Kügler et al. (2003). Human synapsin 1 gene promoter confers highly neuron-specific long-term transgene expression from an adenoviral vector in the adult rat brain. Gene Ther - Kügler 2003 hSyn