Human eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) promoter
Strong ubiquitous promoter (1.2 kb) from human EEF1A1 with superior resistance to epigenetic silencing compared to CMV in both dividing and post-mitotic cells. Preferred for AAV and lentiviral vectors requiring stable long-term expression without promoter attenuation. Lower immunogenicity than CMV makes it the standard housekeeping promoter for human gene therapy applications.
Length: 1179 bp
Strength: Strong
Characteristics
Strong ubiquitous promoter from the human EEF1A1 gene. Resists epigenetic silencing better than CMV in dividing and post-mitotic cells; preferred for stable expression in lentiviral and AAV vectors.
Applications: Broad but less silencing-prone expression than CMV
