Rat collagen type I alpha-1 (Col1a1) promoter

Rat collagen type I alpha-1 (Col1a1) promoter (~3.6 kb); drives high-level expression in fibroblasts and osteoblasts throughout collagen-producing mesenchymal tissues. Used for bone, tendon, and connective tissue-targeted transgene expression.

Length: 3632 bp

Characteristics

Fibroblast and osteoblast-specific promoter (~2.3 kb); drives high-level expression in collagen-producing mesenchymal cells. Used for bone, tendon, and connective tissue-targeted transgene expression.

Sequence

atatagaagccaaggatttcaagggtttccttttctctcttcttctttttttttctttttctttttcctgagatggagtttccttttgtagccctgactgtcctggaattcactctatagaccaggctagcctcacacttagtgatctgcctgcctctgcctcttgggtgctcaggattcaaggcatgaaccaccactacccgaccagggatttcttacacacttctgactggactaaccaggaaagcagagagggagacaggaagaaaatgctcagaaggaaggagtaggattggaggtgagctgggggaacccagactgagccgtgcagaagacaaggaagaagaaagccacccacacacctaggatccacccacagattttgctctgggtacccctgtctggagactgtagggctttgtgatggagggtggggtatgcttcatgccccgtgccctttactccagacctaaatgcccacccccacatacagctgctcgctctctctctcccctgcccttctcccaagagaccagttctccatccctggtctgcagccaaggctgggggcagaagaactttctggaggatttgagtgagaaaagcaagagagcctcaagtagggactggaacctctgggaagggagtgcagaggagacccgggtatgtgccctacctggtacatttatacctgggcagcctctgctcctgttccagacttcagagcccagacgggtcctctccctccctcatgaggggaaacatttggggaaatttggagagagacagaactcagagctcagcactttcctctttctgtttttcttcttgaggaattttttcccccaactgctgatgactttaccattcttgggggtgggggggtggagattctggcttttgctccccctacactccaagtgccggacaaagccctacattccacaagaagccagggcttcagagtttcctaaagatgaggtggcgtggcgagtctcctccctctcccagctccaactccccctcccccagtctccagccctcagcctggccagggaggccccgccaggctgggaggagaccccaagcacattcttcctctcgctgtcatgctgcagaaattaaagacacatctctgagctgggtacccgccaatcgtttcaagttgagaagtggcagaggaggtcccgagcttcagctccatgccacgtgtaaaggaagcttggaacccactgcccacaactcctggggcaaaaacctggagtcagacatggggtgaaggctgtcacacggcacagacacgtcaagcaccccccccaattctagtagtctcctagcctccaccagaaccccagacccttgatgtggcagtcaccagtccacacctgttaggctcttgtctcttcttccagatgagcctggggggcgggggggtgctagatcaggagcagggaaaagtagctttggataagtgcttttcccaatacaaaacccaacaaagagtgggcagatcacactgtgtagtgcttcgtggaaccctaccctagacaactgccttgaacacctattccctctgatgtacaccatccccgtccactgttagggagtgggcatcctttggaactgaccactgtggaaggcaggactttactgagttccggaactaccatctcagcttctcagccccagccttaccctacaggcactggcataggcgggggcagatcctgggccacaagtcactgccacatggttgggataattgatgaagtcctgtccttccattgctgtctccagttctgcttctctggaaactctatatttttccctttaattatagcctctgcagtctccctctgccaccccacccgcaccgcttagcctaactgcccacggccagcgacgtggctccctccccttctgctcccttggtcttttttatttttttttctttgccttcgttgcacaaaactagctcagggagggcgtgaagggggggggagcaatggaatcttggatggtttggaggaggcgggactccttgcttccacgtttacagctctgaagacggctgtgggggaagtgatacaggacgtctatgggccctgagaggagacccctatgcttccctgccacccacacagtttaacaaaatgaagttcctaagtagagtgggggtcaggcagagcacctttgcagggttgatgggagcccagggaaagaaaggacactgtcttttagggacacatttaaatataagccacttttcttgggggacgacaaatgaccctttcctgattgcagaggtggggaacaatggctgagattttcagcaaagaagcgaggacatgaggagtagccttcaaataaagtcactcagctaccaaaaacaagtttctgccacacaccgagttcacctaggtgtccccagaccagatccaagtacagtaaggaaagcaggttctctacagagagaacacggctctatggccaatgccttctacctgctctttctggattgatactgctacctaagagggcctctaaccaattcctggctgtagccacagctgacacaagacctttttctaagacatccctggtcacaggcctcctgtagcaaattccagccctgggatggaggtggtcaggaaagagtttatacaagaagacccaggccacagctttaaggactcagaaacccccctgcccacacggctgcccatcataacgcagaaggtttcttctggaaggacaaggatgtcaaacttctccccaagcctaatcctcagagatgtctccctctgttacacctggggctggagaaaggtgggtctttcatggagccacattcatggcagaacagatagccaccccactcctttcaaacaaccacatatctgactcttagtatctgtgaagagatgtctaatttgttcccaaatattcctaccctgcatacctgggcccacaccatgaggtattctcctccctctaacagtcacatctgcttagctgcctggttcttcggatttggagagatgcttgcctaacttattcttccttaggtcttcccaaggatgccagaaagactatgagacatggccaagaggaccttttcccaattgtgcctgacactgaaccctttgtaatgttccccaactcagattcccaattctacatccttctgatttgaggtcccagaaggaaagtgcaaggggcatcccctacccacaatcagtatatcgagggcccagccacactcagtgatagcacctctggcccatgtagatctgggggacaagggtggcagaattgcaaaggggggagggggctgggtggactcctttcccttcctttccctcctcccccctcttcgttccaaattgggggccgggccaggcagttctgattggctgggggccgggctgctggctccccctctccaagaggcagggttcctcccagccctcctccatcaggatggtataaaaggggcccaggccagtcgtcggagcagacgggagtttcacctccggacggagcaggaggcacacggagtgaggccacgcatgagccgaagctaaccccccaccccagccgcaaagagtctacatgtctagggtctagac

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