Bovine keratin 5 (BK5) promoter

Bovine keratin 5 (BK5) promoter (~5.2 kb); drives expression in basal keratinocytes of stratified squamous epithelia including epidermis and oral mucosa. Used for skin-specific transgene expression in transgenic mouse models of epidermal biology.

Length: 5200 bp

Characteristics

Basal keratinocyte-specific ~5 kb promoter. Drives expression in stratified squamous epithelium (epidermis, oral mucosa, esophagus). Used for skin-targeted transgenic mouse models.

Sequence

gtgtctctcttgggaaaactaacctgttttcatgagccctgaaaacagggctgttggtcctgtggacagcgagcaaggccagcagtttgtgtgcataggggatgtgaaggagctgagaatgcgtgcagagagtgtagctgggctgggaaggtgtccatttgcccccaggactgtccagtctccaggcgtgtttctgaaaccagccctggaaggggtaacatctccagcctctgcactgcttccttttttttttccttccccatgccccagtgatgggagctcaacaccttggagacggaaacaaaactcggtccctgcaccttggcctccgtccttaggatgaggaagccgtccaccaagcagctctcatctccacctccatctttccatccctgggtgtcaagttgctagtatgctgggcgtggaaagaagcagggggaaaaaaaagccatgggggaggttaagggtgagaaaaagttttccggcatgaccccataaggatagaagcctggtgtgaatgaatcatgtccccatctcttcactgtagagaaagtctatagatacccagaggactgagtacacccacacccacatgtaaggaacaaagcaaaggccaagaaaatggtaaaagcccttctttgcaattttagactcattgatgcagagttcataggacaatgtctggtgtacagtaatttttatcagtgtttattaaaagaaaaataaaacctccctccatgagaaagcaaaaccgaggtttttcctgcttatcccttttttagtccctctgactaattaaagtatttgttgatttccagcccatagtttcaatcaaccaagggggattttcaagactttggtatgccattggcaaaacacccatccaatgagggaagaacattccacagacctgcagggacctgtcggagggaggctgagagctctcttgtgtggctctcaccccacaaaagccaatctctcaatcagtctgagaggtgggggctgaggctgcgccccacaatcccctgcatgtgggccccaccctttctgccaaccccggccagcttcaaattaccattcctcctcccgtgagcaaagacccttttcctgctgcttctcccaacaccagtgagggaagccgaggtgagatgttgagcttcctgtccggggttccagcaattcaaaggttggattgagaccaaggcacagcacagggtgaggccatgggcttttgcacctatgctgagacccacaatttgtgtcacgtccaaaggtcccccttgtcaccatgccccaaataatggcaacagagtactcctccacagctgccaagagagaccagttccttttctagtagacttttgcatttctacttgggcctcttctcagatgtgggctctggagagtcctagagaggcagggtggcacccgcagcatcacaaggcagccgccaccagaggtggtcatgtggggagggatgaaggatcctcctcatcctgctgtccacagagaggccgtctcctttctgcccctgcagttctgaaaattctgaatctaagatcaaagctgggacccagagttcccgccgactttgggtggaggcaggagaattcttccctcagttcctccccgaggctagggctttgtaaggagttgtgcgggctggctctgggctctgtccgcccttccccatcttgctggatctggctccatgcactctcggatgaggctgccaaccgtcatccaatgaatagatgactcatgcctcaaccattgtttcccactctttgtgctgaacacgcatggtatagaaggtcctcaaaagtggggacactgcctctttctttctctcctggagggggacatgggagctggggctgagggtgggaggtggggaatgaagggaagttcaaggaatggagagtcacgaactctgtcctcagaggatactcaggctaaaggggataagagatctactctctggatgggaagccagggacagaagtgggtggagaggacccttggactcaggatggggtaggggaaggccttccacaatgacatagggaagggagatgaccttacatctgtcaattcaattcaaaactgtttgctgagcagtactggtgtgcccggctgggctgagtgtgtggcgatgccaaggcaagccagacgtgctccgtaaacctgggggagtctattgtctgggaagacctgcgggtcatatgcaaaaccattgcgcattaaatttatccatcacatggtcttctatgaaaggcacccaaagagtggtgggggccccttggagggagccctggggtgggatcatgggatttgcctagtccttgttccattgtcacctggaccaatcctactccctgcctggtgtgtcagatgtgtccttgtggatgaaatgctgtgcatattctgtgttctcataccttgtgaggatggacagggcagtcacccctgtccccctctgacacggagaccagcaggaccagccactgcagttccctcagtcttgcactcgtctcttgctggaaaatgatgcctggagaagctaattaccatgtcctgccaagccttgataactctctctgtaggtgcctgcagagaggctcagggagctctgtgtaatctctctcttcctgccaggctgaaattccaagctggggtgggactctcccacactgcagtgatgctgggccctggttccctgggggagcatctccactgtggcattgtgggggtggaggggaaggggtggcgtgggggcggccctatctgtttagggaagaattcccacagagagaggtgcttttccctcagcgaggcacccaaacacgcccgaccacattgatttgccacctacacccctttggtccctggcatctgaatctgagcttggcacactccagcccttctcagagtggccagaatgcattcctgttcccctgagtccttctccttcctggacaaggaggaatggagagaaaagaatgtcccagtgtcttgggagggtggggcttccccaagggcagtggagattagactcaggtcaggtgttggtggggggggcgggtaggagggaccatgccctgatggtgacttccaggggagagagaattcccagagagttcccagatagctgcttctgttctgtcggggaatgagggtccacccctatgtctcagggaccccaggatagtcttgtctgttccgtgagaggcaagtgcgaaattggcaagctctgtaaaagtcacctttgagtgcctcaggaattctctagggagggaggcaccaaaatctcattcattgcccaagacttataaggccagctctggccattgatctgtctgtctgtctggacttacttggccactgctgctttctcatcacagcctcaggtgaacaatcacctcttggctgatccccagcggctccgagtcattttcccacagccgtggctgccttgtggctgactgcaggccctgactagaggttcctaagccatggctgggtccttattcctttactctcgagaacatagccactcagtcccgcggcttcaaacccatccccaccctacccctgcctccagcactagcctagggatctcccctaccccaacaactcttaatgacccaaggactgcctgagattcctatttctgttctgacgaggcaaatacaaggccccaatcaggtctgcagccaaaaagatgggatgtgatttaagacagaaatttgtaaaacccaaccaggccacttttcctccatctaataccatagcccacccagataagctttgccgagaggactaactgggagctgggctgagagtgcttcctaaaacaactggcaggtagtcaggccagctgcctggttacccaaacctgccccttctagtctctctggagggatgatccatagatttagaactgcttttccatccccccagccctgaaggagggttcaggctgaagctgagagaaagcccagcaattcccgctgcttggaacggggtggtttgccgttataacaggctggccgactctcgacatgttcctgacgagattaggaactcctgcaggtatgtgtttgtggcggccttcagcctgtatcaacagatacgatgactcatttcttccttagtggaatcaccaagggcttgctggaacacacctggggggctggggagcgggcagagcagctccccctgaagagagacgtgactgccaggtggagtcacaggattctgggggagggttgatggcaagggggccctgggtttgctaagccccctctgggacctgcctgggccaaagggcaaggaaaaagttcaatgcagcagaaaaggctgaattaggaggcgttgtggtgggatgggtctgtccctccagagagcaaagtgggatagaccaggggctgagggtgttccacagtctctgtttctggaacttggttcttggggagactttctggcccaaatcttgcaggagaatctgcccagcaggctctgatgtaactgtgcctcctctaagaaatggagttttgcagtatgtgatggaaatctattttcccctctggcacagagtggagagatcaggccacagctggctttccaagggctgaagtccctgaagcaagctctccctaaaggaataagcagagcagaccactgccagtgggggactcgctctgccccctgttcatggatagtgtgcaatgtgctgcaatgtttgatgacattcctggtcctggaaggatctttcaggatcttggccaaatgcccccttgcttcccagcacccttctttgggctactcacagccctaggccccggctgtaaagaaagatttgctggcagcatggcctattcgctgccaagacatcagggctgcaaggcaagtttatccctagctgagcagagcctgccaggaagacagcgtttgcaccccacaccgctgcgcaggtgtgtcggtgagctcacagctgccccccaggcatgcccagcccacttaatcattcacagctcgacaactctcccgcccaaaccaggtctagaggataaaagcggggcttgcggctcctagataacagagccgctttccgcgtcctgtcccgcgctgctctttctctccagcacctcgcgaccgctagttcccgctactcttactccactaggaaccagccatt

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