Apolipoprotein E hepatic control region/human alpha-1 antitrypsin (ApoE/hAAT) composite promoter
Chimeric liver promoter combining the ApoE enhancer with the human alpha-1 antitrypsin core promoter to achieve hepatocyte-biased expression. Delivers high, stable hepatic expression with reduced extrahepatic activity compared to ubiquitous promoters.
Characteristics
Liver-specific; ApoE hepatic control region (HCR) enhancer fused to minimal hAAT promoter. Strong hepatocyte-selective expression in vivo; widely used in AAV liver-targeted gene therapy vectors.
Applications: Liver and astrocyte-targeted expression. hepatic AAV therapies targeting metabolic or secreted proteins.