A designer AAV variant permits efficient retrograde access to projection neurons

Tervo et al. (2016). Neuron DOI: 10.1016/j.neuron.2016.09.021 Citations: 1353

Parts used

AAV2-Retro Serotype

Key findings

Engineered AAV2-retro through directed evolution with 10-amino acid capsid insertion. Achieved 100-fold improvement in retrograde transport efficiency versus standard AAV2. Revolutionary tool for circuit mapping and gene delivery to projection neurons.