MyoAAV-3A Serotype
Third myoAAV variant with enhanced cardiac muscle tropism within the muscle-targeted series.
Characteristics
M-CREATE evolved with cardiac emphasis. Strong cardiomyocyte transduction. Maintained skeletal muscle targeting. Cross-species efficacy demonstrated. Favorable safety profile.
Applications
Cardiac gene therapy. Heart failure treatments. Cardiomyopathies with systemic delivery.
Literature References
- Tabebordbar et al. (2021). Directed evolution of a family of AAV capsid variants enabling potent muscle-directed gene delivery across species. Cell - Tabebordbar 2021 MyoAAV
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