AAVmyo Serotype
First-generation muscle-targeted AAV from capsid shuffling approach with enhanced muscle specificity and reduced off-target effects.
Characteristics
Capsid shuffling-derived variant. Enhanced muscle specificity versus AAV2 and AAV9. Reduced hepatic and CNS off-target transduction. Improved diaphragm targeting.
Applications
DMD preclinical studies. Respiratory muscle gene therapy. Limb muscle disorders.
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