AAVM41 Serotype
Muscle-specific AAV variant identified through functional screening with superior muscle targeting and reduced immunogenicity.
Characteristics
Functional screening-derived capsid. Superior muscle transduction versus AAV6, AAV8, and AAV9. Reduced immune response profile. Enhanced skeletal and cardiac muscle targeting. Demonstrated efficacy in DMD models.
Applications: Duchenne muscular dystrophy. Other myopathies. Muscle-directed gene therapy with favorable immune profile.
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