AAVM41 Serotype
Muscle-specific AAV variant identified through functional screening with superior muscle targeting and reduced immunogenicity.
Characteristics
Functional screening-derived capsid. Superior muscle transduction versus AAV6, AAV8, and AAV9. Reduced immune response profile. Enhanced skeletal and cardiac muscle targeting. Demonstrated efficacy in DMD models.
Applications
Duchenne muscular dystrophy. Other myopathies. Muscle-directed gene therapy with favorable immune profile.
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