AAV9-F Serotype
AAV9 variant with modified tropism profile for balanced tissue distribution with focus on muscle and cardiac tissue.
Characteristics
Modified biodistribution profile versus wild-type AAV9. Balanced muscle and cardiac transduction. Engineered through rational capsid design.
Applications
Multi-tissue gene therapy applications. Systemic delivery requiring muscle and cardiac coverage.
Literature References
- Pulicherla et al. (2011). Engineering liver-detargeted AAV9 vectors for cardiac and musculoskeletal gene transfer. Mol Ther - Pulicherla 2011 AAV9 Variants
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