AAV7 Serotype
Rhesus macaque-derived serotype with strong liver and skeletal muscle tropism. Part of the expanded AAV toolkit from non-human primate tissue screening.
Characteristics
Discovered from rhesus macaque tissue samples. Strong hepatocyte transduction. Efficient skeletal muscle targeting. Moderate pre-existing immunity. Part of Clade F AAVs. Good transduction efficiency across multiple tissues. Used in comparative serotype studies.
Applications
Liver-directed gene therapy. Metabolic disorders. Muscle-directed applications. Comparative research tool. Alternative to AAV8 for hepatic targeting.
Literature References
- Rutledge et al. (1998). Infectious clones and vectors derived from adeno-associated virus (AAV) serotypes other than AAV type 2. J Virol - Rutledge 1998 AAV6
Related collections
-
AAV Vectors
Adeno-associated viral vectors for in vivo and ex vivo gene delivery. From...
-
CRISPR Tools
Comprehensive CRISPR components for custom genome editing workflows. Guide RNAs, nuclease variants,...
-
Base Editing
Precision single-nucleotide conversion without double-strand breaks. Adenine base editors (A→G), cytosine base...
-
Prime Editing
Search-and-replace genome editing without double-strand breaks or donor templates. Prime editors enable...
