AAV6.2FF Serotype
AAV6.2 variant with dual tyrosine-to-phenylalanine mutations (Y445F+Y731F) preventing ubiquitination and enhancing transduction through improved trafficking.
Characteristics
Y445F and Y731F tyrosine mutations. Prevents ubiquitination and proteasomal degradation. Enhanced intracellular trafficking. 2-5 fold improved transduction versus AAV6.2. Reduced vector dose requirements.
Applications
Muscular dystrophy gene therapy. Liver-directed applications requiring lower vector doses. Enhanced efficiency applications.
Literature References
- Rutledge et al. (1998). Infectious clones and vectors derived from adeno-associated virus (AAV) serotypes other than AAV type 2. J Virol - Rutledge 1998 AAV6
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