AAV5 Serotype

Natural serotype with unique receptor usage and distinct tropism profile. Notable for lower pre-existing immunity and efficient CNS transduction.

Length: 1 bp

Tropism: CNS, retina, lung airway epithelium, liver (moderate)

Characteristics

Uses platelet-derived growth factor receptor (PDGFR) and sialic acid (N-linked glycans) as receptors, not HSPG. Lower pre-existing immunity versus AAV2 (~40% seropositive). Efficient airway epithelial transduction from apical surface. Strong photoreceptor tropism in retina. Moderate liver transduction. Slower intracellular trafficking.

Applications: Retinal gene therapy (alternative to AAV2). Cystic fibrosis and lung disease gene therapy. CNS applications. Photoreceptor-targeted treatments. Applications in antibody-positive patients.

References

  1. Bantel-Schaal et al. (1999). Human adeno-associated virus type 5 is only distantly related to other known primate helper-dependent parvoviruses. J Virol - Bantel-Schaal 1999 AAV5

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