AAV2H22 Serotype
AAV2 variant evolved for enhanced airway epithelial transduction from the apical surface, enabling efficient lung gene delivery.
Characteristics
Peptide insertions conferring apical surface binding. Efficient transduction from airway lumen. Overcomes apical-basolateral polarity barrier. Enhanced respiratory tract tropism.
Applications
Cystic fibrosis gene therapy. Respiratory disease treatments. Alpha-1 antitrypsin deficiency. Lung-directed gene transfer.
Literature References
- Excoffon et al. (2009). Directed evolution of adeno-associated virus to an infectious respiratory virus. Proc Natl Acad Sci USA - Excoffon 2009 AAV2H22
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