AAV2-R100 Serotype
AAV2 variant engineered for enhanced CNS penetration through rational capsid modification with improved neuronal transduction.
Characteristics
Single amino acid substitutions improve neuronal specificity. Reduced glial tropism compared to wild-type AAV2. Enhanced CNS penetration following systemic administration.
Applications
Neurological disorders requiring neuron-specific gene delivery. Preclinical CNS gene therapy research.
Literature References
- Qiao et al. (2017). Adeno-associated virus serotype 6 capsid tyrosine-to-phenylalanine mutations improve gene transfer to skeletal muscle. Mol Ther - Qiao 2017 AAV2 Variants
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