AAV2-7M8 Serotype
Engineered AAV2 variant selected through directed evolution in human hepatocyte xenograft mice. Contains a seven-amino acid insertion at position 588 in the capsid.
Characteristics
20-fold enhanced human hepatocyte transduction versus wild-type AAV2. Demonstrates species-specific tropism improvements. Selected using humanized mouse model platform. Seven-amino acid peptide insertion (LALGETTRP) at capsid position 588.
Applications
Liver-directed gene therapy for metabolic disorders. Hemophilia A and B. Preclinical model for humanized AAV evolution strategies.
Literature References
- Lisowski et al. (2014). Selection and evaluation of clinically relevant AAV variants in a xenograft liver model. Nature - Lisowski 2014 AAV2-7m8
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