AAV2.5T Serotype
Chimeric serotype combining AAV2 and AAV5 capsid sequences for enhanced muscle transduction with improved tissue distribution.
Characteristics
Hybrid capsid structure combining AAV2 and AAV5 sequences. Enhanced muscle transduction efficiency versus parental serotypes. Improved intramuscular spread. Reduced immunogenicity profile.
Applications: Duchenne muscular dystrophy gene therapy. Limb-girdle muscular dystrophies. Cardiac gene therapy applications.
References
- Bowles et al. (2012). Phase 1 gene therapy for Duchenne muscular dystrophy using a translational optimized AAV vector. Mol Ther - Bowles 2012 AAV2.5T
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