AAV-ShH10 Serotype
Simian-human hybrid AAV combining rhesus and human capsid elements for broad tissue tropism with lower pre-existing immunity in human populations.
Characteristics
Hybrid capsid from simian and human AAV sources. Lower pre-existing neutralizing antibodies versus AAV2. Broad tissue tropism across liver, CNS, and muscle. Enhanced transduction efficiency. Favorable immune profile.
Applications
Hemophilia gene therapy. CNS disease applications. Multi-tissue gene therapy requiring broad tropism. Clinical applications in antibody-positive patients.
Literature References
- Choudhury et al. (2016). Viral vectors for therapy of neurologic diseases. Mol Ther - Choudhury 2016 ShH10
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