AAV-PHP.V Serotype
Vascular endothelium-targeted PHP variant for blood vessel gene delivery applications.
Characteristics
Second-generation CREATE for vascular targeting. Enhanced endothelial cell transduction. BBB endothelial specificity. Novel application beyond neuronal gene therapy.
Applications: Vascular biology research. BBB manipulation studies. Endothelial gene therapy approaches.
References
- Huang et al. (2019). Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsids. Neuron - Huang 2019 PHP Variants
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