AAV-PHP.N Serotype
Neuronal-specific PHP variant designed to reduce peripheral organ uptake while maintaining CNS transduction.
Characteristics
Second-generation CREATE for neuronal specificity. Enhanced neuron:glia transduction ratio. Reduced liver, heart, and muscle uptake. Improved CNS selectivity.
Applications
Neuron-specific CNS gene therapy in mice. Reduced peripheral toxicity applications. Selective neuronal circuit manipulation.
Literature References
- Huang et al. (2019). Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsids. Neuron - Huang 2019 PHP Variants
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