AAV-PHP.C2 Serotype

Third-generation CREATE variant engineered for enhanced cardiac tropism with maintained BBB penetration capability.

Length: 1 bp

Tropism: Cardiac muscle, CNS (moderate), skeletal muscle

Characteristics

Third-generation CREATE selection targeting cardiac tissue. Enhanced cardiomyocyte transduction. Retains some CNS penetration. Reduced liver uptake compared to AAV9.

Applications: Cardiac gene therapy in mice. Heart failure research models. Dual cardiac-CNS applications.

References

  1. Challis et al. (2019). Systemic AAV vectors for widespread and targeted gene delivery in rodents. Nat Protoc - Challis 2019 PHP.C

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