AAV-PHP.C2 Serotype
Third-generation CREATE variant engineered for enhanced cardiac tropism with maintained BBB penetration capability.
Characteristics
Third-generation CREATE selection targeting cardiac tissue. Enhanced cardiomyocyte transduction. Retains some CNS penetration. Reduced liver uptake compared to AAV9.
Applications
Cardiac gene therapy in mice. Heart failure research models. Dual cardiac-CNS applications.
Literature References
- Challis et al. (2019). Systemic AAV vectors for widespread and targeted gene delivery in rodents. Nat Protoc - Challis 2019 PHP.C
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