AAV-PHP.B3 Serotype

Third variant from PHP.B CREATE selection, part of the initial BBB-penetrating AAV toolkit. Mouse-specific due to LY6A receptor.

Length: 1 bp

Tropism: CNS (widespread), peripheral nervous system (mouse-specific)

Characteristics

Third independent isolate from CREATE selection. LY6A-dependent BBB transcytosis. Robust CNS transduction in permissive mouse strains. Species and strain-specific limitations.

Applications

Mouse CNS gene therapy research. Neuroscience tool development. Comparative studies with other PHP variants.

Literature References

  1. Deverman et al. (2016). Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain. Nat Biotechnol - Deverman 2016 PHP.B
  2. Hordeaux et al. (2018). The GPI-linked protein LY6A drives AAV-PHP.B transport across the blood-brain barrier. Mol Ther - Hordeaux 2018 LY6A

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