AAV-PHP.B2 Serotype

Second variant from CREATE selection with slightly different CNS transduction profile than PHP.B1. Mouse-specific BBB penetration.

Length: 1 bp

Tropism: CNS (widespread), peripheral nervous system (mouse-specific)

Characteristics

Alternative capsid insertion from same CREATE selection as PHP.B1. LY6A receptor-mediated BBB transport. Similar CNS penetration efficiency to PHP.B1. Mouse strain-dependent performance.

Applications

CNS gene therapy research in mice. Alternative to PHP.B1 for specific experimental paradigms.

Literature References

  1. Deverman et al. (2016). Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain. Nat Biotechnol - Deverman 2016 PHP.B
  2. Hordeaux et al. (2018). The GPI-linked protein LY6A drives AAV-PHP.B transport across the blood-brain barrier. Mol Ther - Hordeaux 2018 LY6A

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