AAV-Hu.37 Serotype

Human tissue-derived serotype with distinct CNS tropism patterns. Part of expanded human AAV diversity screen showing serotype-specific brain region targeting.

Length: 1 bp

Tropism: CNS (region-specific), cortex, striatum, hippocampus, thalamus

Characteristics

Isolated from human tissue samples. Demonstrates serotype-specific CNS transduction patterns. Distinct neuron and glia tropism across brain regions. Efficient cortical, striatal, hippocampal, and thalamic targeting. Part of human AAV phylogenetic clade characterization. Natural human serotype with lower seroprevalence than AAV2.

Applications

CNS gene therapy research. Region-specific brain targeting. Comparative tropism studies. Alternative to AAV2/AAV9 for CNS applications. Neuroscience research tool.

Literature References

  1. Cearley et al. (2008). Expanded repertoire of AAV vector serotypes mediate unique patterns of transduction in mouse brain. Mol Ther - Cearley 2008 AAV Brain

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