AAV-DJ Serotype
First successful chimeric AAV created through DNA family shuffling of AAV2, AAV8, and AAV9. Proof-of-concept for rational capsid engineering and hybrid vector design.
Characteristics
Created via DNA shuffling of AAV2, 8, and 9 capsids. Enhanced transduction across liver, kidney, skeletal muscle, and heart. Demonstrates additive benefits of capsid recombination. Higher efficiency than parental serotypes in multiple tissues. Established methodology for capsid engineering. Good in vitro and in vivo performance.
Applications
Multi-tissue gene therapy research. Proof-of-concept for capsid engineering approaches. Liver and kidney disease studies. Research tool demonstrating hybrid vector potential. Foundation for rational AAV design strategies.
Literature References
- Grimm et al. (2008). In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses. J Virol - Grimm 2008 AAV-DJ
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