Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes

Foust et al. (2009). Nat Biotechnol DOI: 10.1038/nbt.1515 Citations: 1754

Key findings

First demonstration of AAV9 crossing blood-brain barrier after systemic injection. Showed age-dependent tropism with neuronal targeting in neonates and astrocyte targeting in adults.

Parts used

AAV9 Serotype