Programmable C:G to G:C genome editing with CRISPR-Cas9-directed base excision repair proteins
Key Finding
Alternative CGBE architecture manipulating base excision repair pathway using rAPOBEC-nCas9-rXRCC1 or rAPOBEC-nCas9-Polβ fusions. Achieved 15.4% mean C-to-G editing at 68% purity across 27 target sites in multiple cell types.