First discovery and description of adeno-associated virus as contaminant in adenovirus preparations. Foundation for all subsequent AAV research and gene therapy development.
Adenovirus-associated defective virus particles
Key findings
Abstract
Small, DNA-containing particles were separated from preparations of a simian adenovirus. These particles differed antigenically from the adenovirus. Replication of the particles in cell cultures was obtained only when theywere inoculated simultaneously with adenoviruses. This suggests that these adenovirus-associated particles behave as defective viruses.